In Real Life | Parsabiv® (etelcalcetide)

Indication and Limitations of Use:

  • Parsabiv® (etelcalcetide) is indicated for the treatment of secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis. Read More
  • Parsabiv® has not been studied in adult patients with parathyroid carcinoma, primary hyperparathyroidism, or with CKD who are not on hemodialysis and is not recommended for use in these populations. Close
Read Less

In Real Life: Looking at Patients Holistically

Renal dietitians discuss their multipronged approach to patient care
Individual results may vary
  • 1
  • 2
  • 3

Looking at Patients Holistically

Managing Multiple Patients

Why Parsabiv®?

The Insights of Experience

Learn from nephrology professionals on the front lines of dialysis care.

Dialysis Care Team

Portrait of Peer Advocate Anna Chambers

Anna Chambers

Renal Dietitian

Chattanooga, TN
annette-silo

Annette Dillon

RN, Dialysis Facility Manager

LaPlace, LA
jillian-silo

Jillian Golan

Renal Dietitian

Philadelphia, PA
colleen-silo

Colleen Guffee

Renal Dietitian

Columbia, SC
linda-silo

Linda Roberto

Renal Dietitian

Philadelphia, PA

Prescribers

Portrait of Peer Advocate Dr. Abdul Abdellatif

Dr. Abdul Abdellatif

Nephrologist

Houston, TX
Portrait of Peer Advocate Debbie Glidden

Debbie Glidden

Nurse Practitioner

Orlando, FL
Portrait of Peer Advocate Dr. David Henner

Dr. David Henner

Nephrologist

Pittsfield, MA

Experienced Peers

Watch and learn from nephrology professionals who are prescribing and administering Parsabiv® (etelcalcetide).

Play Early Experience video

Early Experience

Play Parsabiv® in Practice video

Parsabiv® in Practice

Play Making a Difference video

Making a Difference

Play Care Team Dynamics video

Care Team Dynamics


Spotlight on Nephrology Podcast

Tune in to this series featuring nephrologists and other nephrology professionals to learn more about Parsabiv® (etelcalcetide) and how changing dynamics are affecting some patients with sHPT.


Real-World Evidence graphic

Look at how Parsabiv® performs in real-world settings

See an analysis of hundreds of real-world treatment experiences.

Icon_Efficacy

EFFICACY

See how Parsabiv® performed
in clinical trials and its use in real-world outcomes

Care TEam Corner Icon

CARE TEAM CORNER

Parsabiv® videos and information
specifically for dietitians, nurses, and technicians

See More

Important Safety Information for Parsabiv®

Contraindication: Parsabiv® (etelcalcetide) is contraindicated in patients with known hypersensitivity to etelcalcetide or any of its excipients. Hypersensitivity reactions, including face edema and anaphylactic reaction, have occurred.

Hypocalcemia: Parsabiv® lowers serum calcium and can lead to hypocalcemia, sometimes severe. Significant lowering of serum calcium can cause QT interval prolongation and ventricular arrhythmia. Patients with conditions that predispose to QT interval prolongation and ventricular arrhythmia may be at increased risk for QT interval prolongation and ventricular arrhythmias if they develop hypocalcemia due

Close

Important Safety Information for Parsabiv®

Contraindication: Parsabiv® (etelcalcetide) is contraindicated in patients with known hypersensitivity to etelcalcetide or any of its excipients. Hypersensitivity reactions, including face edema and anaphylactic reaction, have occurred.

Hypocalcemia: Parsabiv® lowers serum calcium and can lead to hypocalcemia, sometimes severe. Significant lowering of serum calcium can cause QT interval prolongation and ventricular arrhythmia. Patients with conditions that predispose to QT interval prolongation and ventricular arrhythmia may be at increased risk for QT interval prolongation and ventricular arrhythmias if they develop hypocalcemia due to Parsabiv®. Closely monitor corrected serum calcium and QT interval in patients at risk on Parsabiv®.

Significant reductions in corrected serum calcium may lower the threshold for seizures. Patients with a history of seizure disorder may be at increased risk for seizures if they develop hypocalcemia due to Parsabiv®. Monitor corrected serum calcium in patients with seizure disorders on Parsabiv®.

Concurrent administration of Parsabiv® with another oral calcimimetic could result in severe, life-threatening hypocalcemia. Patients switching from cinacalcet to Parsabiv® should discontinue cinacalcet for at least 7 days prior to initiating Parsabiv®. Closely monitor corrected serum calcium in patients receiving Parsabiv® and concomitant therapies known to lower serum calcium.

Measure corrected serum calcium prior to initiation of Parsabiv®. Do not initiate in patients if the corrected serum calcium is less than the lower limit of normal. Monitor corrected serum calcium within 1 week after initiation or dose adjustment and every 4 weeks during treatment with Parsabiv®. Measure PTH 4 weeks after initiation or dose adjustment of Parsabiv®. Once the maintenance dose has been established, measure PTH per clinical practice.

Worsening Heart Failure: In Parsabiv® clinical studies, cases of hypotension, congestive heart failure, and decreased myocardial performance have been reported. Closely monitor patients treated with Parsabiv® for worsening signs and symptoms of heart failure.

Upper Gastrointestinal Bleeding: In clinical studies, 2 patients treated with Parsabiv® in 1253 patient years of exposure had upper gastrointestinal (GI) bleeding at the time of death. The exact cause of GI bleeding in these patients is unknown and there were too few cases to determine whether these cases were related to Parsabiv®.

Patients with risk factors for upper GI bleeding, such as known gastritis, esophagitis, ulcers or severe vomiting, may be at increased risk for GI bleeding with Parsabiv®. Monitor patients for worsening of common Parsabiv® GI adverse reactions and for signs and symptoms of GI bleeding and ulcerations during Parsabiv® therapy.

Adynamic Bone: Adynamic bone may develop if PTH levels are chronically suppressed.

Adverse Reactions: In clinical trials of patients with secondary HPT comparing Parsabiv® to placebo, the most common adverse reactions were blood calcium decreased (64% vs. 10%), muscle spasms (12% vs. 7%), diarrhea (11% vs. 9%), nausea (11% vs. 6%), vomiting (9% vs. 5%), headache (8% vs. 6%), hypocalcemia (7% vs. 0.2%), and paresthesia (6% vs. 1%).

Indication

Parsabiv® (etelcalcetide) is indicated for the treatment of secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis.

Limitations of Use: Parsabiv® has not been studied in adult patients with parathyroid carcinoma, primary hyperparathyroidism, or with CKD who are not on hemodialysis and is not recommended for use in these populations.

Limitations of Use:

Parsabiv® has not been studied in adult patients with parathyroid carcinoma, primary hyperparathyroidism, or with CKD who are not on hemodialysis and is not recommended for use in these populations.

Please see Parsabiv® (etelcalcetide) full Prescribing Information.